Bolen is best-known as a founding member of the garage rock band The Von Bondies. She was their guitarist/vocalist until 2006. Bolen formed The Baby Killers with Jason Stollsteimer in 1997. The band went through various line-up changes, and they eventually changed their name to Von Bondies in 2000. As a member of Von Bondies, she made the NME cool list in 2002 and 2003. Bolen had also played bass in Slumber Party and appeared on their 2001 Psychedelicate recording.

In 2007, Marcie has played live with Patti Smith in Ann Arbor and New York[citation needed]. She is currently playing in the bands Silverghost and F'ke Blood. She also has a country-inspired band with Taylor Hollingsworth. Marcie records demos for her bands at her home in Ferndale, Michigan.

As an artist, she goes by the nickname "Twirlyred."[citation needed] She had worked on the cover booklet for White Stripes' 2001 White Blood Cells LP.